Newcastle United will look to hang onto the sixth spot on the table as they try to qualify for the Conference League when they battle Manchester United on Wednesday in a key English Premier League matchup. It will be Manchester United's last game of the season at Old Trafford, where they are 9-3-6 this season. The Magpies (17-6-13), who have outscored their last five opponents 14-5, are 3-1-1 against Manchester United over their last five meetings. The Red Devils (16-6-14), who have been outscored 8-5 over the past four matches, are coming off a 1-0 loss to Arsenal on Sunday.

The match from Manchester, England, will begin at 3 p.m. ET. Newcastle is the +135 favorite (risk $100 to win $135) on the money-line, while Manchester United is a +160 underdog. A draw will return +300 in the latest Manchester United vs. Newcastle odds, and the over-under for total goals is 3.5. (For more soccer coverage, click here).

Before you lock in your Manchester United vs. Newcastle picks or English Premier League predictions, you NEED to see what SportsLine's soccer expert Brandt Sutton has to say.

Sutton, a former collegiate soccer player, has been SportsLine's top soccer editor for more than five years. He has followed soccer closely for much longer and factors in managerial tactics, projected lineups and past performances to make the most-informed decisions possible, keeping his finger on the pulse of the game all over the globe.

Sutton finished 2022 as SportsLine's top soccer expert with a 165-130-2 mark, returning nearly $2,200 for $100 players, and is 139-136-5 since the 2022 World Cup.

Sutton knows Newcastle forward Alexander Isak is among the league leaders in goals, and has been red hot of late. In 28 appearances, including 25 starts, he has registered 20 goals and one assist. The 24-year-old from Sweden has taken 68 shots, including 37 on target. He has registered five goals over the past five matches, including two matches with a pair of goals. In a 5-1 win over Sheffield on April 27, he scored two goals on five shots, with three on target. He also had a pair of goals in a 4-0 win over Tottenham Hotspur on April 13. In that match, he took five shots with two on net.

The expert is also aware Manchester United forward Rasmus Hojlund will look to provide some offense, especially if midfielder Bruno Fernandes misses another match. In 28 appearances, including 25 starts, Hojlund has registered eight goals and two assists. He has taken 34 shots, including 17 on net. He scored a goal on three shots, including two on target, in a 4-2 win over Sheffield United on April 24. Since turning pro in 2020-2021, he has scored 26 goals in 97 league appearances for Copenhagen, Sturm Graz, Atalanta and Manchester United.

Sutton has taken an in-depth look at the Manchester United vs. Newcastle showdown. He has locked in one CONFIDENT best bet and is offering a full breakdown of this English Premier League match! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

Who wins Manchester United vs. Newcastle on Wednesday, and what are the best bets you can make? ... Join SportsLine now to see Brandt Sutton's picks for Manchester United vs. Newcastle, all from the insider who has his finger on the pulse of the game all over the world!